tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

Base Information

• Chemical Name: tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate
• CAS No.: 130406-52-9
• Molecular Formula: C₃₂H₄₀N₄O₃
• Molecular Weight: 528.695

Synonyms:tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

Chemical Property of tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

There total 29 articles about tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tricyclo<3.3.1.13,7>dec-2-yl *,S*)>-<2-<<1-(azidomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-51-8) → tricyclo<3.3.1.13,7>dec-2-yl *,S*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-52-9)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 30 ℃; under 2585.7 Torr;

DOI:10.1021/jm00105a062

Reference yield:

1-adamantanol (700-57-2) → tricyclo<3.3.1.13,7>dec-2-yl *,S*)>-<2-<<1-(aminomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate (130406-52-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / Et₃N / tetrahydrofuran / 0.25 h

3: 90 percent / LiOH / H₂O; dioxane / 18 h / Ambient temperature

4: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

5: 95 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1021/jm00105a062

Reference yield:

1-adamantanol (700-57-2) → [(R)-1-((R)-1-Aminomethyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester (130406-52-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / Et₃N / tetrahydrofuran / 0.25 h

3: 90 percent / LiOH / H₂O; dioxane / 18 h / Ambient temperature

4: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

5: AcOH, H₂ / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1021/jm00105a062

upstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-<2-<<1-(azidomethyl)-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

1-adamantanol

(9-fluorenylmethoxycarbonyl)-L-phenylalaninol

2-adamantyl chloroformate

Downstream raw materials:

PD 135118

tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*(E)>>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,12-trioxo-6-(phenylmethyl)-13-oxa-2,5,8-triazatetradec-10-enoate

tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,13-trioxo-6-(phenylmethyl)-14-oxa-2,5,8-triazapentadecanoate

tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,11-trioxo-6-(phenylmethyl)-12-oxa-2,5,8-triazatridecanoate

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