{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

Base Information

Chemical Name:{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid
CAS No.:322765-92-4
Molecular Formula:C₄₉H₅₁NO₁₃
Molecular Weight:861.943
Hs Code.:

{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1<i>H</i>-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

Synonyms:{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

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Chemical Property of {5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

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Technology Process of {5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

There total 8 articles about {5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 322765-91-3
{3,4-bis-(3,4-dimethoxy-phenyl)-5-[(3,4-dimethoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonyl)-methyl]-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid 2,2,2-trichloro-ethyl ester

: 322765-92-4
{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

Guidance literature:: With ammonium acetate; zinc; In tetrahydrofuran; at 25 ℃; for 1.5h;
DOI:10.1016/S0040-4039(00)01614-2

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 322765-92-4
{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: DCC; DMAP / CH₂Cl₂ / 15 h / 15 °C

2: NBS; AIBN / CCl₄ / 1 h / 35 °C / Irradiation

3: 57 percent / acidic Al₂O₃ / CHCl₃ / 10 h / Heating

4: 89 percent / Zn dust; aq. NH₄OAc / tetrahydrofuran / 1.5 h / 25 °C

With dmap; aluminum oxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonium acetate; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; tetrachloromethane; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(00)01614-2

Reference yield:

: 2460-33-5
3,4-dimethoxyphenylpyruvic acid

: 322765-92-4
{5-[carboxy-(3,4-dimethoxy-phenyl)-methyl]-3,4-bis-(3,4-dimethoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-1H-pyrrol-2-yl}-(3,4-dimethoxy-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: I₂ / tetrahydrofuran / -78 - 25 °C

2.1: 4 Angstroem mol. sieves / tetrahydrofuran / 18 h

3.1: 95 percent / TFA / CHCl₃ / 10 h / Heating

4.1: 57 percent / acidic Al₂O₃ / CHCl₃ / 10 h / Heating

5.1: 89 percent / Zn dust; aq. NH₄OAc / tetrahydrofuran / 1.5 h / 25 °C

With aluminum oxide; n-butyllithium; 4 A molecular sieve; ammonium acetate; trifluoroacetic acid; zinc; In tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4039(00)01614-2