(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

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Chemical Name:(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide
CAS No.:926299-89-0
Molecular Formula:C₂₂H₂₇ClF₃N₃O₄S
Molecular Weight:521.988
Hs Code.:

Synonyms:(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

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Chemical Property of (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

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Technology Process of (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

There total 8 articles about (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}propenoic acid

: 98138-19-3
1-(3-methyl)butanesulfonamide

: 926299-89-0
(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

Guidance literature:: (E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}propenoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃;

1-(3-methyl)butanesulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1016/j.bmc.2011.12.008

Reference yield:

: 1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(methoxymethoxy)-1H-pyrazole-5-carboxylic acid

: 926299-89-0
(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: hydrogenchloride / ethanol; water / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

7.2: 100 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008

Reference yield:

: 926296-32-4
ethyl (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(methoxymethoxy)-1H-pyrazol-5-yl]propenoate

: 926299-89-0
(E)-3-{1-[2-chloro-4-(trifluoromethyl)benzyl]-3-isopropoxy-1H-pyrazol-5-yl}-N-[(3-methylbutyl)sulfonyl]propenamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol; water / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

4.2: 100 °C

With hydrogenchloride; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.008