(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Base Information

Chemical Name:(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol
CAS No.:144149-10-0
Molecular Formula:C₂₇H₃₁FN₂O
Molecular Weight:418.554
Hs Code.:

Synonyms:(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Suppliers and Price of (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

There total 4 articles about (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144148-78-7
ethyl (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenoate

: 144149-10-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; for 0.5h; Yield given;
DOI:10.1021/jm00075a024

Reference yield:

: 2-(4-tert-butylbenzyl)cyclohexanone

: 144149-10-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) diisopropylamine, n-BuLi / 1.) hexane, THF, -78 deg C, 45 min, 2.) hexane, THF, RT, overnight

2: 1.) NaOAc, 2.) aq. HCl / 1.) MeOH, from RT, overnight to reflux, 2 h, 2.) THF, reflux, 4 h

3: 100 percent / NaH / tetrahydrofuran / Ambient temperature

4: (i-Bu)2AlH / tetrahydrofuran; toluene / 0.5 h

With hydrogenchloride; n-butyllithium; sodium acetate; sodium hydride; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm00075a024

Reference yield:

: 144147-77-3
6-(4-tert-butylbenzyl)-2-(2,2-dimethoxyacetyl)cyclohexanone

: 144149-10-0
(E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOAc, 2.) aq. HCl / 1.) MeOH, from RT, overnight to reflux, 2 h, 2.) THF, reflux, 4 h

2: 100 percent / NaH / tetrahydrofuran / Ambient temperature

3: (i-Bu)2AlH / tetrahydrofuran; toluene / 0.5 h

With hydrogenchloride; sodium acetate; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm00075a024