tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

Base Information

Chemical Name:tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate
CAS No.:643093-80-5
Molecular Formula:C₂₁H₂₆ClIN₂O₃
Molecular Weight:516.807
Hs Code.:

Synonyms:tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

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Chemical Property of tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

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Technology Process of tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

There total 2 articles about tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₁₆H₁₈ClIN₂O

: 24424-99-5
di-tert-butyl dicarbonate

: 643093-80-5
tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h; pH=8 - 8.5;
DOI:10.1021/jm8000345

Reference yield:

: 288392-34-7
(RS)-2-chloro-5-(oxiran-2-yl)pyridine

: 24424-99-5
di-tert-butyl dicarbonate

: 76471-50-6
[(1R)-2-(4-iodophenyl)-1-methylethyl]amine

: 643093-80-5
tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

Guidance literature:: In tetrahydrofuran; ethanol;

Reference yield:

: 855482-72-3
[3-(cyclohexyloxy)-4-(methoxycarbonyl)phenyl]boronic acid

: 643093-80-5
tert-butyl [(2R)-2-(6-chloro-3-pyridinyl)-2-hydroxyethyl][(1R)-2-(4-iodophenyl)-1-methylethyl]carbamate

: C₃₅H₄₃ClN₂O₆

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm8000345