N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide

Base Information

Chemical Name:N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide
CAS No.:354993-05-8
Molecular Formula:C₁₇H₁₇NO₄
Molecular Weight:299.326
Hs Code.:
DSSTox Substance ID:DTXSID801329007
ChEMBL ID:CHEMBL1731741

Synonyms:Oprea1_320621;Oprea1_855654;MLS001217297;CHEMBL1731741;DTXSID801329007;HMS1694O16;HMS2891J12;N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide;N-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-2-phenoxy-acetamide;AKOS000550026;SMR000611158;EU-0043516;SR-01000480316;SR-01000480316-1;Z29885204;354993-05-8

Suppliers and Price of N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:299.11575802
Heavy Atom Count:22
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(OC2=CC=CC=C2O1)CNC(=O)COC3=CC=CC=C3

Technology Process of N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide

There total 1 articles about N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-phenoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4442-59-5
(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)amine

: 122-59-8
2-phenoxyacetic acid

: 354993-05-8
N₁-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-phenoxyacetamide

Guidance literature:: 2-phenoxyacetic acid; With triethylamine; isobutyl chloroformate; In dichloromethane; at 0 ℃; for 0.333333h;

(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)amine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/S0968-0896(01)00395-9

Reference yield: 73.0%

: 354993-05-8
N₁-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-phenoxyacetamide

: 2170-41-4
WB 4082

Guidance literature:: With dimethylsulfide borane complex; In 1,2-dimethoxyethane; at 80 ℃;
DOI:10.1016/S0968-0896(01)00395-9

Reference yield:

: 354993-05-8
N₁-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-phenoxyacetamide

: 449195-29-3
2-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)(2-phenoxyethyl)amino]-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / BH₃*SMe₂ / 1,2-dimethoxy-ethane / 80 °C

2: 51 percent / K₂CO₃ / ethanol / 72 h / 110 °C

With dimethylsulfide borane complex; potassium carbonate; In 1,2-dimethoxyethane; ethanol;
DOI:10.1016/S0968-0896(01)00395-9