(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

Base Information

Chemical Name:(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde
CAS No.:205505-74-4
Molecular Formula:C₁₆H₂₂O₆
Molecular Weight:310.347
Hs Code.:

Synonyms:(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

Chemical Property:

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Technology Process of (S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

There total 5 articles about (S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 205505-70-0
(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carboxylic acid ethyl ester

: 205505-74-4
(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;
DOI:10.3987/COM-97-S24

Reference yield:

: 7402-30-4
2-(3,4,5-trimethyloxy)benzylmalonic acid diethyl ester

: 205505-74-4
(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / KOH / ethanol / Ambient temperature

2: 77 percent / NaH / tetrahydrofuran / Heating

3: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

4: 93 percent / p-TsOH / tetrahydrofuran / Ambient temperature

5: 46 percent / DIBALH / toluene / 0.5 h / -78 °C

With potassium hydroxide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; ethanol; water; toluene; tert-butyl alcohol;
DOI:10.3987/COM-97-S24

Reference yield:

: 205505-53-9
2-(3,4,5-Trimethoxy-benzyl)-acrylic acid ethyl ester

: 205505-74-4
(S)-2,2-Dimethyl-4-(3,4,5-trimethoxy-benzyl)-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

2: 93 percent / p-TsOH / tetrahydrofuran / Ambient temperature

3: 46 percent / DIBALH / toluene / 0.5 h / -78 °C

With diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; water; toluene; tert-butyl alcohol;
DOI:10.3987/COM-97-S24