(S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate

Base Information

• Chemical Name: (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate
• CAS No.: 1334484-98-8
• Molecular Formula: C₂₀H₃₄O₅Si
• Molecular Weight: 382.572
• Mol file: 1334484-98-8.mol

Synonyms:(S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate

Chemical Property of (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate

There total 7 articles about (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H36O6Si → (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate (1334484-98-8)

Guidance literature:

C₂₀H₃₆O₆Si; With caesium carbonate; In methanol; at 25 ℃; for 3h; Inert atmosphere;

With acetic acid; In methanol; for 18h; Inert atmosphere;

DOI:10.1021/ol202320m

Reference yield:

(S)-1-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-6-(triisopropylsilyloxy)heptane-2,4-dione (1192264-05-3) → (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate (1334484-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 1 h / Reflux; Inert atmosphere

2.1: caesium carbonate / methanol / 3 h / 25 °C / Inert atmosphere

2.2: 18 h / Inert atmosphere

With caesium carbonate; In methanol; toluene;

DOI:10.1021/ol202320m

Reference yield:

(5S)-allyl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-(triisopropylsilyloxy)hexanoate (1334484-97-7) → (S)-methyl 2,4-dihydroxy-6-(2-(tri-isopropylsilyloxy)propyl)benzoate (1334484-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.92 h / 0 - 25 °C / Inert atmosphere

2.1: toluene / 1 h / Reflux; Inert atmosphere

3.1: caesium carbonate / methanol / 3 h / 25 °C / Inert atmosphere

3.2: 18 h / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ol202320m

upstream raw materials:

(S)-1-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-6-(triisopropylsilyloxy)heptane-2,4-dione

(5S)-allyl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-(triisopropylsilyloxy)hexanoate

triisopropylsilyl trifluoromethanesulfonate

(S)-3-(tri-isopropylsilyloxy)butanoic acid

Downstream raw materials:

C₁₁H₁₄O₅