Vardenafil hydrochloride

Base Information

• Chemical Name: Vardenafil hydrochloride
• CAS No.: 224785-91-5
• Molecular Formula: C23H33ClN6O4S
• Molecular Weight: 525.06
• Hs Code.: 2933299090
• Mol file: 224785-91-5.mol

Synonyms:Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-,monohydrochloride (9CI);Levitra;

Chemical Property of Vardenafil hydrochloride

Chemical Property:

• Appearance/Colour: White to off-white cyrstalline solid
• Vapor Pressure: 5.17E-19mmHg at 25°C
• Melting Point: 214-216 °C
• Boiling Point: 692.2 °C at 760 mmHg
• Flash Point: 372.5 °C
• PSA: 121.28000
• LogP: 3.82900

Purity/Quality:

99%min ^*data from raw suppliers

2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulphonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Vardenafil was the second agent to be marketed and had the advantage that its onset time was not reduced by taking the medication on a full stomach . It is 30 times more potent as an inhibitor of PDE5 (mean IC50, 3.9 nM) than sildenafil and 10 times more potent than tadalafil, with a greater selectivity (>1,000 times) for human PDE5 than for human PDE2, PDE3, and PDE4 and moderate selectivity (>80 times) for PDE1. The PDE inhibitory selectivity and both the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5, with an IC50 of 0.7 nM (sildenafil 6.6 nM). The IC50 of vardenafil for PDE1 was 180 nM, for PDE6 11 nM, and for PDE2, PDE3 and PDE4 more than 1,000 nM.
• Uses: vardenafil hydrochloride is a selective phsphodiesterase type 5 (pde5) inhibitor that is used as a urological agent in the treatment of erectile dysfunction.