4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene

Base Information

• Chemical Name: 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene
• CAS No.: 150501-77-2
• Molecular Formula: C₁₅H₂₆O₂Si
• Molecular Weight: 266.456
• Mol file: 150501-77-2.mol

Synonyms:4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene

Chemical Property of 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene

There total 5 articles about 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Ethyl 4-<1-(tert-butyldimethylsiloxy)ethyl>benzoate (150501-70-5) → 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene (150501-77-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Heating;

DOI:10.1021/jo00071a023

Reference yield: 68.0%

4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene (150501-75-0) → 4-(1-hydroxyethyl)benzyl alcohol (80463-22-5) + 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene (150501-77-2) + 1-(4-Triisopropylsilanyloxymethyl-phenyl)-ethanol

Guidance literature:

With fluorosilicic acid; In tert-butyl alcohol; for 34h;

DOI:10.1021/jo00071a023

Reference yield:

1-(tert-butyldimethylsilyloxymethyl)-4-(1'-(tert-butyldimethylsilyloxy)ethyl)benzene (1174669-38-5) → 4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-(hydroxymethyl)benzene (150501-77-2)

Guidance literature:

With (F)TBAF; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo901245m

upstream raw materials:

Ethyl 4-<1-(tert-butyldimethylsiloxy)ethyl>benzoate

4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

ethyl-4-acetylbenzoate

4-[1-hydroxyethyl]benzoic acid ethyl ester

Downstream raw materials:

4-<1-(tert-Butyldimethylsiloxy)ethyl>-1-<(triisopropylsiloxy)methyl>benzene

4-(1-hydroxyethyl)benzyl alcohol