3-Amino-4-bromopyridine

Base Information

• Chemical Name: 3-Amino-4-bromopyridine
• CAS No.: 239137-39-4
• Molecular Formula: C5H5BrN2
• Molecular Weight: 173.012
• Hs Code.: 2933399090
• European Community (EC) Number: 678-655-2
• DSSTox Substance ID: DTXSID20376592
• Nikkaji Number: J1.145.059H
• Wikidata: Q72438903
• Mol file: 239137-39-4.mol

Synonyms:3-Amino-4-bromopyridine;239137-39-4;4-bromopyridin-3-amine;4-BROMO-PYRIDIN-3-YLAMINE;3-Pyridinamine, 4-bromo-;MFCD04112575;SCHEMBL758890;DTXSID20376592;LKQGBXRGSPSTES-UHFFFAOYSA-N;BBL100699;STL554493;3-Amino-4-bromopyridine, AldrichCPR;AKOS005199045;AB17638;AC-1846;CS-W004805;SB36007;SY025389;TS-02360;A4975;AM20061792;FT-0649980;EN300-170243;W-206864

Chemical Property of 3-Amino-4-bromopyridine

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 34.741mmHg at 25°C
• Refractive Index: 1.333
• Boiling Point: 287.6 °C at 760 mmHg
• PKA: 3.88±0.10(Predicted)
• Flash Point: 127.7 °C
• PSA: 38.91000
• Density: 1.71 g/cm³
• LogP: 2.00750
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 171.96361
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-4-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC(=C1Br)N

Technology Process of 3-Amino-4-bromopyridine

There total 1 articles about 3-Amino-4-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-azidopyridine (39910-67-3) → 4-aminopyridine (504-24-5) + 3-amino-4-bromopyridine (239137-39-4)

Guidance literature:

With hydrogen bromide; Ambient temperature; Irradiation;

Reference yield: 94.0%

3-amino-4-bromopyridine (239137-39-4) → 4-iodopyridin-3-amine (105752-11-2)

Guidance literature:

With copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium iodide; In 1,4-dioxane; at 110 ℃; for 24h;

DOI:10.1016/j.chembiol.2009.11.016

Reference yield: 91.0%

3-amino-4-bromopyridine (239137-39-4) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 4-(3,5-dichlorophenyl)pyridin-3-amine

Guidance literature:

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; at 60 ℃;

upstream raw materials:

4-azidopyridine

Downstream raw materials:

4-bromo-N-phenylpyridin-3-amine

4-Bromo-3-(2-bromoanilino)pyridine

betacarboline

4-Bromo-3-[2-bromo-N-(methylsulfonyl)anilino]pyridine