β-MAPI

Base Information

• Chemical Name: β-MAPI
• CAS No.: 83830-00-6
• Molecular Formula: C₃₀H₄₁N₇O₆
• Molecular Weight: 595.699
• Mol file: 83830-00-6.mol

Synonyms:β-MAPI

Chemical Property of β-MAPI

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-MAPI

There total 6 articles about β-MAPI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-phenylalanine tert-butyl ester (16874-17-2) → β-MAPI (83830-00-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 85.9 percent / acetonitrile / 2.5 h / 20 °C

2.1: N-methylmorpholine / CH₂Cl₂

2.2: 70 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 99 percent / H₂ / Pd/C / acetic acid / 2.5 h / 20 °C

4.1: N-methylmorpholine / tetrahydrofuran / 0 °C

4.2: 90 percent / EDCI; HOBt / CH₂Cl₂ / 0 - 20 °C

5.1: 92 percent / H₂ / Pd/C / acetic acid / 4.5 h / 20 °C

6.1: 63 percent / PDC; 4 Angstroem molecular sieves; celite 545 / CH₂Cl₂ / 3.5 h / 20 °C

7.1: MeSO₃H; anisole / 0.67 h / 20 °C

With 4-methyl-morpholine; dipyridinium dichromate; methanesulfonic acid; 4 A molecular sieve; Celite; hydrogen; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;

DOI:10.1016/S0040-4020(01)00323-4

Reference yield:

L-phenylalanine t-butyl ester N-hydroxysuccinimide carboxamide (189563-82-4) → β-MAPI (83830-00-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-methylmorpholine / CH₂Cl₂

1.2: 70 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: 99 percent / H₂ / Pd/C / acetic acid / 2.5 h / 20 °C

3.1: N-methylmorpholine / tetrahydrofuran / 0 °C

3.2: 90 percent / EDCI; HOBt / CH₂Cl₂ / 0 - 20 °C

4.1: 92 percent / H₂ / Pd/C / acetic acid / 4.5 h / 20 °C

5.1: 63 percent / PDC; 4 Angstroem molecular sieves; celite 545 / CH₂Cl₂ / 3.5 h / 20 °C

6.1: MeSO₃H; anisole / 0.67 h / 20 °C

With 4-methyl-morpholine; dipyridinium dichromate; methanesulfonic acid; 4 A molecular sieve; Celite; hydrogen; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;

DOI:10.1016/S0040-4020(01)00323-4

Reference yield:

C27H37N5O8S (189563-90-4) → β-MAPI (83830-00-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-methylmorpholine / tetrahydrofuran / 0 °C

1.2: 90 percent / EDCI; HOBt / CH₂Cl₂ / 0 - 20 °C

2.1: 92 percent / H₂ / Pd/C / acetic acid / 4.5 h / 20 °C

3.1: 63 percent / PDC; 4 Angstroem molecular sieves; celite 545 / CH₂Cl₂ / 3.5 h / 20 °C

4.1: MeSO₃H; anisole / 0.67 h / 20 °C

With 4-methyl-morpholine; dipyridinium dichromate; methanesulfonic acid; 4 A molecular sieve; Celite; hydrogen; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;

DOI:10.1016/S0040-4020(01)00323-4

upstream raw materials:

C₄₁H₅₅N₇O₉S

L-phenylalanine tert-butyl ester

L-phenylalanine t-butyl ester N-hydroxysuccinimide carboxamide

C₂₇H₃₇N₅O₈S

Downstream raw materials:

β-MAPI dimethyl acetal monomethyl ester

1-hydroxy-3-phenylpropan-2-one

L-valine

N-<(S)-1-carboxy-2-phenylethyl>carbamoyl-L-arginine