(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

Base Information

Chemical Name:(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester
CAS No.:270257-64-2
Molecular Formula:C₂₅H₃₀N₂O₆Se
Molecular Weight:533.483
Hs Code.:

Synonyms:(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

Chemical Property:

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Technology Process of (3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

There total 8 articles about (3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 270257-63-1
(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-hydroxyethyl)-L-proline methyl ester

: 270257-64-2
(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

Guidance literature:: With tributylphosphine; In tetrahydrofuran;
DOI:10.1021/jo991649t

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 270257-64-2
(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / N-ethylmorpholine / CH₂Cl₂ / 0 - 20 °C

2.1: 87 percent / tetraethylammonium tosylate / Electrolysis

3.1: 77 percent / BF₃*Et₂O / diethyl ether / -40 - 20 °C

4.1: O₃ / methanol; CH₂Cl₂ / 0.33 h / -78 °C

4.2: 75 percent / NaBH₄ / methanol; CH₂Cl₂ / -78 - 20 °C

5.1: 72 percent / tributylphosphine / tetrahydrofuran

With N-ethylmorpholine;; tributylphosphine; boron trifluoride diethyl etherate; tetraethylammonium tosylate; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Substitution / 2.1: Oxidation / 3.1: Substitution / 4.1: Oxidation / 4.2: Reduction / 5.1: Substitution;
DOI:10.1021/jo991649t

Reference yield:

: 212612-51-6
(3R)-N-tert-butyloxycarbonyl-5-methoxy-3-phenyl-L-proline methyl ester

: 270257-64-2
(3R,5R)-N-tert-butyloxycarbonyl-3-phenyl-5-(2'-o-nitrophenylseleno)ethyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / BF₃*Et₂O / diethyl ether / -40 - 20 °C

2.1: O₃ / methanol; CH₂Cl₂ / 0.33 h / -78 °C

2.2: 75 percent / NaBH₄ / methanol; CH₂Cl₂ / -78 - 20 °C

3.1: 72 percent / tributylphosphine / tetrahydrofuran

With tributylphosphine; boron trifluoride diethyl etherate; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Substitution / 2.1: Oxidation / 2.2: Reduction / 3.1: Substitution;
DOI:10.1021/jo991649t