tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate
CAS No.:1361323-07-0
Molecular Formula:C₂₄H₃₉N₃O₃
Molecular Weight:417.592
Hs Code.:

Synonyms:tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

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Technology Process of tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

There total 4 articles about tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: (S)-1-phenethylpiperidin-3-amine dihydrochloride

: 1361323-07-0
tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

Guidance literature:: N-tert-butyloxycarbonyl-L-tert-leucine; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

(S)-1-phenethylpiperidin-3-amine dihydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1361323-07-0
tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 4.25 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 1361322-88-4
(S)-tert-butyl 1-phenethylpiperidin-3-ylcarbamate

: 1361323-07-0
tert-butyl (S)-3,3-dimethyl-1-oxo-1-((S)-1-phenethylpiperidin-3-ylamino)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109