(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

Base Information

• Chemical Name: (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin
• CAS No.: 1160524-50-4
• Molecular Formula: C₂₃H₂₄N₂O₆S
• Molecular Weight: 456.519

Synonyms:(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

Chemical Property of (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

There total 1 articles about (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (220509-74-0,1110670-49-9) + 2-[4-(chloromethyl)phenyl]oxirane → (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin (1160524-50-4)

Guidance literature:

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

2-[4-(chloromethyl)phenyl]oxirane; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8.5h; Inert atmosphere;

DOI:10.1021/jm8015014

Reference yield: 51.0%

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin (1160524-50-4) → (S)-1-[4-(1-fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1160524-56-0)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In dichloromethane; for 2h; regioselective reaction; Inert atmosphere; Heating;

DOI:10.1021/jm8015014

Reference yield:

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin (1160524-50-4) → (S)-1-[4-(1-[(18)F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1160524-60-6)

Guidance literature:

With [⁽¹⁸⁾F]Et₃N*3HF; In acetonitrile; at 120 ℃; for 0.75h; regioselective reaction;

DOI:10.1021/jm8015014

upstream raw materials:

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Downstream raw materials:

(S)-1-[4-(1-fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

(S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1160524-50-4 (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

Send

Send

Metric Ton KG G Pound L ML

Send

Send