(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

Base Information

Chemical Name:(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester
CAS No.:134848-73-0
Molecular Formula:C₃₇H₅₇N₃O₁₀
Molecular Weight:703.874
Hs Code.:

(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

Synonyms:(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

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Chemical Property of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

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Technology Process of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

There total 2 articles about (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 121533-54-8
(4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid

: 134848-72-9
Z-Glu(2-hydroxyethyl)-OtBu

: 134848-73-0
(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;
DOI:10.1021/jm00113a005

Reference yield:

: 34897-61-5
N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt

: 134848-73-0
(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-[2-((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-ethyl] ester 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / hydrobenzotriazole monohydrate (HOBt), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 - 20 °C

2: 97 percent / 4-(dimethylamino)pyridine (DMAP), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm00113a005