methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

Base Information

Chemical Name:methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate
CAS No.:75384-97-3
Molecular Formula:C₁₇H₂₀ClNO₃
Molecular Weight:321.804
Hs Code.:

Synonyms:methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

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Chemical Property of methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

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Technology Process of methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

There total 4 articles about methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 75385-05-6
methyl rac-7-(2-chlorophenyl)-3,4,6,7,8,9-hexahydro-2-oxo-2H-quinolizine-1-carboxylate

: 75384-97-3
methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In 1,2-dimethoxyethane; toluene; at -30 - -20 ℃; for 1h;
DOI:10.1021/jm00368a011

Reference yield:

: 37734-05-7
Methyl 3-oxo-4-pentenoate

: 75384-97-3
methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / p-toluenesulfonic acid / methanol / 20 h / Ambient temperature

2: 81 percent / diisobutylaluminum hydride / 1,2-dimethoxy-ethane; toluene / 1 h / -30 - -20 °C

With diisobutylaluminium hydride; toluene-4-sulfonic acid; In methanol; 1,2-dimethoxyethane; toluene;
DOI:10.1021/jm00368a011

Reference yield:

: 87922-77-8
5-(2-chlorophenyl)-2-piperidone

: 75384-97-3
methyl rac-(1αH,9αβH)-7β-(2-chlorophenyl)octahydro-2-oxo-2H-quinolizine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) aq. K₂CO₃ / 1.) CH₂Cl₂, a) reflux, 4 h, b) RT, 15 h, 2.) CH₂Cl₂, RT, 2 h

2: 54 percent / p-toluenesulfonic acid / methanol / 20 h / Ambient temperature

3: 81 percent / diisobutylaluminum hydride / 1,2-dimethoxy-ethane; toluene / 1 h / -30 - -20 °C

With diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; 1,2-dimethoxyethane; toluene;
DOI:10.1021/jm00368a011