16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate

Base Information

• Chemical Name: 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate
• CAS No.: 1425471-28-8
• Molecular Formula: C₂₆H₄₄O₃SSi
• Molecular Weight: 464.785
• Mol file: 1425471-28-8.mol

Synonyms:16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate

Chemical Property of 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate

There total 3 articles about 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

16-(trimethylsilyl)hexadec-15-yn-1-ol (215236-62-7) + p-toluenesulfonyl chloride (98-59-9) → 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate (1425471-28-8)

Guidance literature:

With pyridine; In chloroform;

DOI:10.1002/anie.201206221

Reference yield:

hexadec-7-yn-1-ol (822-21-9) → 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate (1425471-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride; Trimethylenediamine / methanol / 24 h / 20 - 69 °C

2: n-butyllithium / tetrahydrofuran / 20 °C

3: pyridine / chloroform

With pyridine; n-butyllithium; sodium hydride; Trimethylenediamine; In tetrahydrofuran; methanol; chloroform;

DOI:10.1002/anie.201206221

Reference yield:

hexadec-15-yn-1-ol (62914-53-8) → 16-(trimethylsilyl)hexadec-15-yn-1-yl 4-toluenesulfonate (1425471-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / 20 °C

2: pyridine / chloroform

With pyridine; n-butyllithium; In tetrahydrofuran; chloroform;

DOI:10.1002/anie.201206221

upstream raw materials:

hexadec-7-yn-1-ol

hexadec-15-yn-1-ol

16-(trimethylsilyl)hexadec-15-yn-1-ol

p-toluenesulfonyl chloride

Downstream raw materials:

4-[(17R,19R,24S,25R)-17,19-dihydroxy-25-methoxy-24-methylheptacos-1-ynyl]phenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside