5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

Base Information

Chemical Name:5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester
CAS No.:96734-81-5
Molecular Formula:C₂₀H₁₇F₃N₂O₄S
Molecular Weight:438.427
Hs Code.:

Synonyms:5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

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Technology Process of 5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

There total 2 articles about 5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 13669-10-8
ethyl 2-thenoylacetate

: 35229-84-6
chloro{[3-(trifluoromethyl)phenyl]hydrazono}-acetic acid, ethyl ester

: 96734-81-5
5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; for 24h; Ambient temperature;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 96734-81-5
5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium nitrite, 6N HCl; 2.) sodium acetate / 1.) water; 2.) water, ethanol, 0 - 5 deg C, 3 h -> overnight

2: 52 percent / sodium ethoxide / ethanol / 24 h / Ambient temperature

With hydrogenchloride; sodium ethanolate; sodium acetate; sodium nitrite; In ethanol;