[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Base Information

Chemical Name:[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine
CAS No.:259268-44-5
Molecular Formula:C₂₉H₃₅FN₂O
Molecular Weight:446.608
Hs Code.:

Synonyms:[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Suppliers and Price of [1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of [1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

There total 4 articles about [1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 332-42-3
(2-bromoethyl)-4-fluorobenzene

: 259268-43-4
3-(aminomethyl)-1-[2-(bisphenylmethoxy)ethyl]piperidine

: 259268-44-5
[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/jm9902178

Reference yield:

: 4138-26-5,168749-30-2
nipecotamide

: 259268-44-5
[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 84 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

3: 60 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Alkylation;
DOI:10.1021/jm9902178

Reference yield:

: 6305-20-0
2-bromoethyl benzhydryl ether

: 259268-44-5
[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 84 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

3: 60 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Alkylation;
DOI:10.1021/jm9902178