methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate

Base Information

• Chemical Name: methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate
• CAS No.: 1410795-79-7
• Molecular Formula: C₃₉H₅₀Br₂N₆O₂S₂
• Molecular Weight: 858.805
• Mol file: 1410795-79-7.mol

Synonyms:methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate

Chemical Property of methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate

There total 2 articles about methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 3,7-dioxocholan-24-oate (7753-72-2) + 4-(p-bromophenyl)thiosemicarbazide (2646-31-3) → methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate (1410795-79-7)

Guidance literature:

With hydrogenchloride; aluminum oxide; In neat (no solvent); for 0.075h; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.09.083

Reference yield:

3β,7α-dihydroxy-5β-cholan-24-oic acid (566-24-5) → methyl (5β)-3,7-bis[2-[[(4-bromophenyl)amino]thioxomethyl]hydrazinylidene]-cholan-24-oate (1410795-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid

2: pyridinium chlorochromate / dichloromethane

3: aluminum oxide; hydrogenchloride / neat (no solvent) / 0.07 h / Microwave irradiation

With hydrogenchloride; aluminum oxide; toluene-4-sulfonic acid; pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/j.bmcl.2012.09.083

upstream raw materials:

methyl 3,7-dioxocholan-24-oate

4-(p-bromophenyl)thiosemicarbazide

3β,7α-dihydroxy-5β-cholan-24-oic acid