ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate

Base Information

• Chemical Name: ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate
• CAS No.: 1352042-59-1
• Molecular Formula: C₃₄H₃₅NO₅
• Molecular Weight: 537.656
• Mol file: 1352042-59-1.mol

Synonyms:ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate

Chemical Property of ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate

There total 1 articles about ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-ethyl 3-(4-bromo-3-nitrophenyl)acrylate (860778-52-5) + 3-(1-adamantyl)-4-benzyloxyphenylboronic acid (221137-01-5) → ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate (1352042-59-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/jm2011436

Reference yield: 100.0%

ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate (1352042-59-1) → ethyl (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-nitrocinnamate (1352042-65-9)

Guidance literature:

ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate; With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With water; In dichloromethane; Inert atmosphere;

DOI:10.1021/jm2011436

Reference yield: 99.0%

ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-nitrocinnamate (1352042-59-1) → ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-aminocinnamate (1352042-73-9)

Guidance literature:

With tin(II) chloride hydrate; In ethanol; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm2011436

upstream raw materials:

(E)-ethyl 3-(4-bromo-3-nitrophenyl)acrylate

3-(1-adamantyl)-4-benzyloxyphenylboronic acid

Downstream raw materials:

ethyl (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-nitrocinnamate

(E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-nitrocinnamic acid

ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-aminocinnamate

ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-bromocinnamate