3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

Base Information

Chemical Name:3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione
CAS No.:238427-81-1
Molecular Formula:C₁₅H₂₀N₄O₂
Molecular Weight:288.349
Hs Code.:

Synonyms:3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

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Chemical Property of 3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

Chemical Property:

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Technology Process of 3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

There total 4 articles about 3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 699-51-4
1,3-diazaspiro[4.4]nonane-2,4-dione

: 238427-81-1
3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / triphenylphosphine, diethyl azodicarboxylate / dimethylformamide / 24 h

2: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

With hydrogenchloride; hydrogen; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9706325

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 238427-81-1
3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / triphenylphosphine, diethyl azodicarboxylate / dimethylformamide / 24 h

2: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

With hydrogenchloride; hydrogen; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9706325

Reference yield:

: 238427-79-7
3-<2-(4-nitrophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

: 238427-81-1
3-<2-(4-hydrazinophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

2: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

With hydrogenchloride; hydrogen; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm9706325