2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

Base Information

Chemical Name:2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile
CAS No.:1373934-10-1
Molecular Formula:C₂₄H₂₂ClN₃O
Molecular Weight:403.911
Hs Code.:

Synonyms:2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

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Chemical Property of 2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

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Technology Process of 2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

There total 3 articles about 2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 126-81-8
dimedone

: 587-04-2
m-Chlorobenzaldehyde

: 62-53-3
aniline

: 109-77-3
malononitrile

: 1373934-10-1
2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

Guidance literature:: dimedone; aniline; In ethanol; for 24h; Reflux;

m-Chlorobenzaldehyde; malononitrile; With 1H-imidazole; In ethanol; water; at 60 ℃; for 2h; Reagent/catalyst; Temperature;
DOI:10.1002/jccs.201200359

Reference yield:

: 126-81-8
dimedone

: 1373934-10-1
2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: water / Reflux

2: 1,4-diaza-bicyclo[2.2.2]octane; tetraethylammonium bromide / water / 0.42 h / Reflux; Green chemistry

With 1,4-diaza-bicyclo[2.2.2]octane; tetraethylammonium bromide; In water;

Reference yield:

: 62-53-3
aniline

: 1373934-10-1
2-amino-4-(3-chlorophenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-phenylquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: water / Reflux

2: 1,4-diaza-bicyclo[2.2.2]octane; tetraethylammonium bromide / water / 0.42 h / Reflux; Green chemistry

With 1,4-diaza-bicyclo[2.2.2]octane; tetraethylammonium bromide; In water;