N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester
• CAS No.: 81444-73-7
• Molecular Formula: C₃₁H₃₀N₄O₅
• Molecular Weight: 538.603
• Mol file: 81444-73-7.mol

Synonyms:N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester

Chemical Property of N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester

There total 4 articles about N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester (81444-73-7)

Guidance literature:

Reference yield:

N-(benzyloxycarbonyl)-D-tryptophan (2279-15-4) → N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester (81444-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triethylamine / dimethylformamide / -10 °C / 1.) 5 min, 2.) 30 min

2: triethylamine / dimethylformamide / 1.) -10 deg C, 3 h, 2.) room temperature

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00375a011

Reference yield:

(S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) + C22H22N2O6 → N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester (81444-73-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Yield given; 1.) -10 deg C, 3 h, 2.) room temperature;

DOI:10.1021/ja00375a011

upstream raw materials:

(S)-tryptophan methyl ester hydrochloride

L-tryptophan methyl ester

N-(benzyloxycarbonyl)-D-tryptophan

Downstream raw materials:

Z-(D)-Trp-(L)-Trp-(L)-Pro-PNP

Z-(D)-Trp-(L)-Trp(COOH)