2,3-Dihydroxy-4-methoxybenzaldehyde

Base Information

• Chemical Name: 2,3-Dihydroxy-4-methoxybenzaldehyde
• CAS No.: 4055-69-0
• Molecular Formula: C8H8O4
• Molecular Weight: 168.149
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID30468513
• Nikkaji Number: J3.550.821J
• Wikidata: Q82295741
• Mol file: 4055-69-0.mol

Synonyms:2,3-Dihydroxy-4-methoxybenzaldehyde;4055-69-0;2,3-dihydroxy-4-methoxy-benzaldehyde;DHMB;Isovanillinalkohol;2,3-dihydroxy4-methoxy-benzaldehyde;Benzaldehyde, 2,3-dihydroxy-4-methoxy-;SCHEMBL1527154;DTXSID30468513;OJZYLUUHIAKDJT-UHFFFAOYSA-N;2,3-Dihydroxy-4methoxy-benzaldehyde;MFCD00016589;2, 3-dihydroxy-4-methoxybenzaldehyde;AKOS000277714;2,3,-dihydroxy-4-methoxy-benzaldehyde;DS-5264;CS-0150636;FT-0703916;J3.550.821J;C75056;2,3-dihydroxy-4-methoxybenzaldehyde, AldrichCPR;A825167

Chemical Property of 2,3-Dihydroxy-4-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 69.5 °C
• Refractive Index: 1.631
• Boiling Point: 299.047 °C at 760 mmHg
• PKA: 7.63±0.15(Predicted)
• Flash Point: 123.631 °C
• PSA: 66.76000
• Density: 1.378 g/cm³
• LogP: 0.91890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 168.04225873
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dihydroxy-4-methoxybenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)C=O)O)O

Technology Process of 2,3-Dihydroxy-4-methoxybenzaldehyde

There total 15 articles about 2,3-Dihydroxy-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3,4-trimethoxybenzaldehyde (2103-57-3) → 2,3-dihydroxy-4-methoxybenzaldehyde (4055-69-0)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1002/bkcs.10605

Reference yield: 90.0%

2-hydroxy-4-methoxy-3-methoxymethoxybenzaldehyde (160820-50-8) → 2,3-dihydroxy-4-methoxybenzaldehyde (4055-69-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.666667h;

DOI:10.3987/COM-00-S(I)40

Reference yield: 85.0%

2-bromoisovanillin (2973-58-2) → 2,3-dihydroxy-4-methoxybenzaldehyde (4055-69-0)

Guidance literature:

With sodium hydroxide; copper(II) sulfate; for 5h; Heating;

DOI:10.1007/BF00576219

upstream raw materials:

3-methocycatechol

2-bromoisovanillin

orthoformic acid triethyl ester

2,3,4-trimethoxybenzaldehyde

Downstream raw materials:

4-methoxy-2,3-methylenedioxy-benzaldehyde

1-methoxy-2,3,4-trihydroxybenzene

8-hydroxy-7-methoxy-2H-chromen-2-one

2,3,4-trimethoxybenzaldehyde