ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate

Base Information

• Chemical Name: ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate
• CAS No.: 1294452-94-0
• Molecular Formula: C₂₀H₁₇ClO₃
• Molecular Weight: 340.806
• Mol file: 1294452-94-0.mol

Synonyms:ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate

Chemical Property of ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate

There total 2 articles about ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2,3-dihydro-1H-inden-1-ol (33781-38-3,147592-14-1) + 3-(4-chlorophenyl)-2-propionic acid ethyl ester (1030828-84-2) → ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate (1294452-94-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 6h; cooling with ice;

Reference yield:

→ ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate (1294452-94-0)

Guidance literature:

Reference yield:

ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate (1294452-94-0) → C18H13ClO3 (1312788-42-3)

Guidance literature:

ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate; With lithium hydroxide monohydrate; water; In ethanol; at 60 - 80 ℃; for 3h;

With hydrogenchloride; In ethanol; water;

upstream raw materials:

5-chloro-2,3-dihydro-1H-inden-1-ol

3-(4-chlorophenyl)-2-propionic acid ethyl ester

Downstream raw materials:

C₁₈H₁₃ClO₃