tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)

Base Information

• Chemical Name: tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)
• CAS No.: 1456632-82-8
• Molecular Formula: C₃₆H₄₀Br₂O₈
• Molecular Weight: 760.517
• Mol file: 1456632-82-8.mol

Synonyms:tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)

Chemical Property of tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)

There total 1 articles about tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,4-bis(bromomethyl)benzene (623-24-5) + diethyl 2-(4-bromobenzyl)malonate (70146-78-0) → tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate) (1456632-82-8)

Guidance literature:

diethyl 2-(4-bromobenzyl)malonate; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 0 ℃; for 0.5h;

1,4-bis(bromomethyl)benzene; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1002/pola.26738

Reference yield: 78.0%

tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate) (1456632-82-8) → tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate) (1456632-83-9)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 160 ℃; for 7h;

DOI:10.1002/pola.26738

Reference yield:

tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate) (1456632-82-8) → 1,4-bis(2-(4-bromobenzyl)-3-methyl-3-((triethylsilyl)oxy)butyl)benzene (1456632-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; lithium chloride / dimethyl sulfoxide / 7 h / 160 °C

2.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 0.5 h / -78 °C

2.2: 2 h / -78 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 1H-imidazole; cerium(III) chloride; water; lithium chloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/pola.26738

upstream raw materials:

1,4-bis(bromomethyl)benzene

diethyl 2-(4-bromobenzyl)malonate

Downstream raw materials:

1,4-bis(2-(4-bromobenzyl)-3-methyl-3-((triethylsilyl)oxy)butyl)benzene

tetraethyl 2,2'-(1,4-phenylenebis(methylene))bis(2-(4-bromobenzyl)malonate)

4,4'-(1,4-phenylene)bis(3-(4-bromobenzyl)-2-methylbutan-2-ol)

1,4-bis(2-(4-ethynylbenzyl)-3-methyl-3-((triethylsilyl)oxy)butyl)benzene