2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid

Base Information

• Chemical Name: 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid
• CAS No.: 1315479-43-6
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.262
• Mol file: 1315479-43-6.mol

Synonyms:2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid

Chemical Property of 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid

There total 3 articles about 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

CH3O4S(1-)*C15H15ClNO2(1+) (1315479-40-3) → 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid (1315479-43-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; for 2h; Reflux;

DOI:10.1139/v11-048

Reference yield:

2-chloropyridine-4-boronic acid (458532-96-2) → 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid (1315479-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere

2: acetonitrile / 6 h / Reflux

3: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile; 1: Suzuki-Miyaura cross-coupling;

DOI:10.1139/v11-048

Reference yield:

methyl 2-(2-chloropyridin-4-yl)phenylacetate (1218999-69-9) → 2-(1-methyl-2-oxo-1,2-dihydropridin-4-yl)phenylacetic acid (1315479-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 6 h / Reflux

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / Reflux

With water; lithium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1139/v11-048

upstream raw materials:

methyl 2-(2-chloropyridin-4-yl)phenylacetate

CH₃O₄S^(1-)*C₁₅H₁₅ClNO₂⁽¹⁺⁾

2-chloropyridine-4-boronic acid