[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

Base Information

Chemical Name:[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester
CAS No.:221536-90-9
Molecular Formula:C₃₅H₃₈N₂O₉
Molecular Weight:630.695
Hs Code.:

[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

Synonyms:[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

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Chemical Property of [(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

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Technology Process of [(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

There total 8 articles about [(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 221536-87-4
[(2S,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

: 221536-90-9
[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(99)00147-1

Reference yield:

: 3-Benzyloxymethyl-1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 221536-90-9
[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaH / dimethylformamide / 2 h / 0 °C

2: Bu₄NF / tetrahydrofuran / 3 h / 0 °C

3: 79 percent / DMAP, pyridine / 24 h / 50 °C

4: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 30 h / Ambient temperature

5: 70 percent / tetrahydrofuran / 14 h / 65 °C

6: 69 percent / conc.HCl(aq) / methanol / 36 h / 50 °C

7: 98 percent / H₂ / Pd-C (10 percent) / methanol / 24 h / 760 Torr / Ambient temperature

8: 95 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00147-1

Reference yield:

: 221536-67-0
3-benzyloxymethyl-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 221536-90-9
[(2S,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 30 h / Ambient temperature

2: 70 percent / tetrahydrofuran / 14 h / 65 °C

3: 69 percent / conc.HCl(aq) / methanol / 36 h / 50 °C

4: 98 percent / H₂ / Pd-C (10 percent) / methanol / 24 h / 760 Torr / Ambient temperature

5: 95 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(99)00147-1