3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

Base Information

Chemical Name:3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one
CAS No.:176981-30-9
Molecular Formula:C₅₆H₅₇NO₉Si
Molecular Weight:916.155
Hs Code.:

3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

Synonyms:3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

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Chemical Property of 3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

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Technology Process of 3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

There total 8 articles about 3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 176981-29-6
3-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-1,3,6',7',8',9'-hexahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1-ol

: 176981-30-9
3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

Guidance literature:: With Ph₃BiCO₃; In pyridine; toluene; at 90 ℃; for 3h;
DOI:10.1016/0040-4020(96)00245-1

Reference yield:

: 145222-84-0
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate

: 176981-30-9
3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 5 min, 2.) hexane, THF, -78 deg C, 3 h

2: 83 percent / DDQ / CH₂Cl₂ / 0.17 h / Ambient temperature

3: 80 percent / K₂CO₃ / acetone / 12 h / Heating

4: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

5: 66 percent / CF₃COOAg / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

6: 1.) n-BuLi / 1.) hexane, THF, Et₂O, -78 deg C, 10 min, 2.) hexane, THF, Et₂O, -78 deg C, 15 min

7: 79 percent / Et₃B, Ph₃SnH / hexane; benzene / 0.5 h

8: 88 percent / Ph₃BiCO₃ / toluene; pyridine / 3 h / 90 °C

With n-butyllithium; triethyl borane; Ph₃BiCO₃; triphenylstannane; potassium tert-butylate; silver trifluoroacetate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In pyridine; diethyl ether; hexane; dichloromethane; acetone; toluene; benzene;
DOI:10.1016/0040-4020(96)00245-1

Reference yield:

: 176981-13-8
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methoxy-5a,7,8,9a-tetrahydro-5H,6H-benzo[g]isoquinoline-9,10-dione

: 176981-30-9
3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / DDQ / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 80 percent / K₂CO₃ / acetone / 12 h / Heating

3: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

4: 66 percent / CF₃COOAg / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

5: 1.) n-BuLi / 1.) hexane, THF, Et₂O, -78 deg C, 10 min, 2.) hexane, THF, Et₂O, -78 deg C, 15 min

6: 79 percent / Et₃B, Ph₃SnH / hexane; benzene / 0.5 h

7: 88 percent / Ph₃BiCO₃ / toluene; pyridine / 3 h / 90 °C

With n-butyllithium; triethyl borane; Ph₃BiCO₃; triphenylstannane; potassium tert-butylate; silver trifluoroacetate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In pyridine; diethyl ether; hexane; dichloromethane; acetone; toluene; benzene;
DOI:10.1016/0040-4020(96)00245-1