(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1146159-35-4
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about (R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 708289-25-2
C₁₅H₁₂N₂O₂

: 1146159-35-4
(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; sodium hydroxide / water / 20 h / Reflux

2: trichlorophosphate / 4.5 h / Reflux

3: boron tribromide / dichloromethane / 24 h

4: triethylamine / dichloromethane

With dihydrogen peroxide; boron tribromide; triethylamine; sodium hydroxide; trichlorophosphate; In dichloromethane; water;
DOI:10.1021/jm101150b

Reference yield:

: 1028-96-2
2-(2-methoxyphenyl)quinazolin-4-ol

: 1146159-35-4
(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 4.5 h / Reflux

2: boron tribromide / dichloromethane / 24 h

3: triethylamine / dichloromethane

With boron tribromide; triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.1021/jm101150b

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 1146159-35-4
(R)-3-[2-(2-hydroxy-phenyl)-quinazolin-4-yl-amino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / diethyl ether / 24 h / Reflux

2: dihydrogen peroxide; sodium hydroxide / water / 20 h / Reflux

3: trichlorophosphate / 4.5 h / Reflux

4: boron tribromide / dichloromethane / 24 h

5: triethylamine / dichloromethane

With dihydrogen peroxide; boron tribromide; potassium carbonate; triethylamine; sodium hydroxide; trichlorophosphate; In diethyl ether; dichloromethane; water;
DOI:10.1021/jm101150b