3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

Base Information

Chemical Name:3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione
CAS No.:1413913-94-6
Molecular Formula:C₂₉H₃₇N₅O₄SSi
Molecular Weight:579.795
Hs Code.:

Synonyms:3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

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Chemical Property of 3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

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Technology Process of 3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

There total 6 articles about 3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37868-77-2
3-ethyl-1,3-thiazolidine-2,4-dione

: 1413912-54-5
4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-2-ylamino) benzaldehyde

: 1413913-94-6
3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

Guidance literature:: With piperidinyl acetate; In ethanol; water; at 20 ℃; for 6h; Reflux;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413913-94-6
3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

4.2: 4 h / 110 °C

5.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

6.1: piperidinyl acetate / ethanol; water / 6 h / 20 °C / Reflux

With piperidinyl acetate; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; caesium carbonate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1413913-94-6
3-ethyl-5-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 21.17 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

3.2: 4 h / 110 °C

4.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

5.1: piperidinyl acetate / ethanol; water / 6 h / 20 °C / Reflux

With piperidinyl acetate; diethyl aluminiumcholoride; sodium hydride; caesium carbonate; pyridinium chlorochromate; In ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;