[3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

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Chemical Name:[3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone
CAS No.:1426917-64-7
Molecular Formula:C₂₅H₂₂FN₅O₂
Molecular Weight:443.48
Hs Code.:

Synonyms:[3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

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Chemical Property of [3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

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Technology Process of [3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

There total 10 articles about [3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: C₃₈H₄₃FN₅O₅PolS

: 1426917-64-7
[3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 65 ℃; for 0.5h;

Reference yield: 37.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 1426918-44-6
4-[6-(4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-3-vinyl-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

: 1426917-64-7
[3-[(E)-2-(4-fluoro-phenyl)-vinyl]-6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-piperazin-1-yl-methanone

Guidance literature:: With hydrogenchloride; tetrabutyl ammonium fluoride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 - 100 ℃; for 9h; Inert atmosphere;