(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Base Information

Chemical Name:(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one
CAS No.:104293-51-8
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

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Chemical Property of (3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

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Technology Process of (3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

There total 7 articles about (3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 104293-40-5
(5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methylenedihydrofuran-2(4H)-one

: 104293-51-8
(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;
DOI:10.1021/jo00371a001

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 104293-51-8
(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / sulfur trioxide, pyridine, triethylamine, DMSO / CH₂Cl₂ / 1 h / 0 °C

2: 1.) chlorotitanium triisopropoxide / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, a.) -78 deg C, 15 min, b.) 0 deg C, 30 min

3: 100 mg / H₂ / 10percent Pd/C / ethyl acetate / 24 h

4: xylene / 14 h / Heating

With pyridine; triisopropoxytitanium(IV) chloride; sulfur trioxide; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; xylene;
DOI:10.1021/jo00371a001

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 104293-51-8
(3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) chlorotitanium triisopropoxide / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, a.) -78 deg C, 15 min, b.) 0 deg C, 30 min

2: 100 mg / H₂ / 10percent Pd/C / ethyl acetate / 24 h

3: xylene / 14 h / Heating

With triisopropoxytitanium(IV) chloride; hydrogen; palladium on activated charcoal; In ethyl acetate; xylene;
DOI:10.1021/jo00371a001