cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

Base Information

• Chemical Name: cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one
• CAS No.: 138335-27-0
• Molecular Formula: C₂₄H₂₉F₃N₂O
• Molecular Weight: 418.502

Synonyms:cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

Chemical Property of cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

There total 7 articles about cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1-nitro-3-(trifluoromethyl)benzene (6656-49-1) → cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one (138335-27-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 73 percent / NaH / dimethylformamide / 5 h

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: 92 percent / H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: 75 percent / MeONa / methanol / 3 h / Heating

5: LiBr / dimethylformamide / 4 h / Heating

6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00082a020

Reference yield:

2-(4-Ethyl-benzylidene)-malonic acid dimethyl ester (138334-75-5) → cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one (138335-27-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 73 percent / NaH / dimethylformamide / 5 h

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: 92 percent / H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: 75 percent / MeONa / methanol / 3 h / Heating

5: LiBr / dimethylformamide / 4 h / Heating

6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00082a020

Reference yield:

<1-(4-ethylphenyl)-2-<2-nitro-6-(trifluoromethyl)phenyl>ethyl>propanedioic acid, dimethyl ester (138384-05-1) → cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-1-<2-(dimethylamino)ethyl>-4-(4-ethylphenyl)-2H-1-benzazepin-2-one (138335-27-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

2: 92 percent / H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

3: 75 percent / MeONa / methanol / 3 h / Heating

4: LiBr / dimethylformamide / 4 h / Heating

5: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00082a020

upstream raw materials:

cis-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-methyl-4-(4-ethylphenyl)-2H-1-benzazepin-2-one

2-(dimethylamino)ethyl chloride

2-methyl-1-nitro-3-(trifluoromethyl)benzene

2-(4-Ethyl-benzylidene)-malonic acid dimethyl ester

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