tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate

Base Information

• Chemical Name: tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate
• CAS No.: 1289154-99-9
• Molecular Formula: C₁₆H₂₄N₂O₄S
• Molecular Weight: 340.444
• Mol file: 1289154-99-9.mol

Synonyms:tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate

Chemical Property of tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate

There total 1 articles about tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

3(S)-(tert-butoxycarbonylamino)pyrrolidine (122536-76-9,140629-77-2) + benzenesulfonyl chloride (1939-99-7) → tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate (1289154-99-9)

Guidance literature:

3(S)-(tert-butoxycarbonylamino)pyrrolidine; With potassium carbonate; In water; ethyl acetate; for 0.416667h;

benzenesulfonyl chloride; In tetrahydrofuran; water; ethyl acetate; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2011.01.020

Reference yield: 93.2%

tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate (1289154-99-9) → (S)-1-(benzylsulfonyl)pyrrolidin-3-aminium chloride (1289155-00-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate (1289154-99-9) → (S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-chlorobenzyl)piperazin-1-yl)ethanone (1289155-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: potassium iodide / tetrahydrofuran / 20 h / Reflux

With hydrogenchloride; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.ejmech.2011.01.020

upstream raw materials:

3(S)-(tert-butoxycarbonylamino)pyrrolidine

benzenesulfonyl chloride

Downstream raw materials:

(S)-1-(benzylsulfonyl)pyrrolidin-3-aminium chloride

(S)-1-(4-benzylpiperazin-1-yl)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)ethanone

(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-methylbenzyl)piperazin-1-yl)ethanone

(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(3-methylbenzyl)piperazin-1-yl)ethanone