[(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester

Base Information

• Chemical Name: [(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester
• CAS No.: 868609-89-6
• Molecular Formula: C₁₆H₂₃BrN₂O₂
• Molecular Weight: 355.275
• Mol file: 868609-89-6.mol

Synonyms:[(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester

Chemical Property of [(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester

There total 1 articles about [(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) + 1,4-bromoiodobenzene (589-87-7) → [(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester (868609-89-6)

Guidance literature:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester; 1,4-bromoiodobenzene; With potassium phosphate; copper(l) iodide; ethylene glycol; In isopropyl alcohol; at 90 ℃;

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 1h;

Reference yield: 100.0%

[(R)-1-(4-bromo-phenyl)-piperidin-3-yl]-carbamic acid-tert-butylester (868609-89-6) → (R)-1-(4-bromo-phenyl)-piperidin-3-ylamine (868609-90-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

upstream raw materials:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

1,4-bromoiodobenzene

Downstream raw materials:

(R)-1-(4-bromo-phenyl)-piperidin-3-ylamine