5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Base Information

Chemical Name:5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one
CAS No.:1262859-77-7
Molecular Formula:C₁₂H₁₁BrF₃NO₂
Molecular Weight:338.124
Hs Code.:

Synonyms:5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

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Chemical Property of 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Chemical Property:

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Technology Process of 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

There total 3 articles about 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416434-92-8
N-[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-propionamide

: 1262859-77-7
5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Guidance literature:: With potassium hydroxide; In acetonitrile;

Reference yield:

: 1262860-80-9
[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

: 1262859-77-7
5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; dichloromethane; 1,4-dioxane

2: potassium hydroxide / acetonitrile

With potassium hydroxide; In 1,4-dioxane; hydrogenchloride; dichloromethane; acetonitrile;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1262859-77-7
5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -70 - -60 °C

1.2: -40 °C

2.1: toluene / 18 h / 90 °C

2.2: 1 h / -78 - -60 °C

3.1: sodium hydrogencarbonate; ozone / methanol; dichloromethane; oxygen / 0.17 h / -78 °C

3.2: 0.67 h / -78 - 0 °C

3.3: Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: potassium hydroxide / acetonitrile

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; ozone; diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; oxygen; toluene; acetonitrile;