4-(trifluoromethyl)phenylphosphonous dichloride

Base Information

• Chemical Name: 4-(trifluoromethyl)phenylphosphonous dichloride
• CAS No.: 774-99-2
• Molecular Formula: C₇H₄Cl₂F₃P
• Molecular Weight: 246.984
• Mol file: 774-99-2.mol

Synonyms:4-(trifluoromethyl)phenylphosphonous dichloride

Chemical Property of 4-(trifluoromethyl)phenylphosphonous dichloride

Chemical Property:

• Boiling Point: 92-93 °C(Press: 14 Torr)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(trifluoromethyl)phenylphosphonous dichloride

There total 5 articles about 4-(trifluoromethyl)phenylphosphonous dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bis(diethylamino)(4-(trifluoromethyl)phenyl)phospine (311820-23-2) → 4-(trifluoromethyl)phenylphosphonous dichloride (774-99-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -78 - 20 ℃; for 12h;

DOI:10.1002/chem.200401296

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) → 4-(trifluoromethyl)phenylphosphonous dichloride (774-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; diethyl ether / 1 h / 5 °C

1.2: hexane; diethyl ether / 5 - 20 °C

2.1: 20.9 g / HCl / diethyl ether / 12 h / -78 - 20 °C

With hydrogenchloride; n-butyllithium; In diethyl ether; hexane;

DOI:10.1002/chem.200401296

Reference yield:

(4-(trifluoromethyl)phenyl)zinc(II) chloride (125102-17-2) → 4-(trifluoromethyl)phenylphosphonous dichloride (774-99-2)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.1c01560

upstream raw materials:

Bis(diethylamino)(4-(trifluoromethyl)phenyl)phospine

p-trifluoromethylphenyl bromide

(4-trifluoromethylphenyl)lithium

(4-(trifluoromethyl)phenyl)zinc(II) chloride

Downstream raw materials:

difluoro-(4-trifluoromethyl)-phosphine oxide

C₇H₄F₅P