Technology Process of ethyl 2-(2-ethynylphenoxy)acetate
There total 2 articles about ethyl 2-(2-ethynylphenoxy)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo300063u
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran;
DOI:10.1021/jo300063u
- Guidance literature:
-
ethyl 2-(2-ethynylphenoxy)acetate;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
Inert atmosphere;
With
hydrogenchloride;
In
water;
pH=4;
DOI:10.1021/jo300063u
