2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

Base Information

• Chemical Name: 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid
• CAS No.: 874301-24-3
• Molecular Formula: C₂₆H₂₄N₆O₃
• Molecular Weight: 468.515
• Mol file: 874301-24-3.mol

Synonyms:2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

Chemical Property of 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

There total 12 articles about 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dinitrobenzoic acid (528-45-0) → 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid (874301-24-3)

Guidance literature:

Multi-step reaction with 7 steps

1: thionyl chloride / 2 h / 80 °C

2: 7.79 g / pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

3: hydrogen / Pd/C / ethanol / 4 h / 20 °C

4: 3.69 percent / sodium pyrosulfite / ethanol; H₂O / 6 h / Heating

5: 84 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 46 h / -40 - 4 °C

6: 768 mg / sodium pyrosulfite / ethanol; H₂O / 20 h / Heating

7: NaOH / 0.5 h / 70 °C

With pyridine; sodium hydroxide; sodium disulfite; lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1021/jo051836t

Reference yield:

3,4-dinitrobenzoyl chloride (24376-18-9) → 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid (874301-24-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 7.79 g / pyridine / CH₂Cl₂ / 3.5 h / 0 - 20 °C

2: hydrogen / Pd/C / ethanol / 4 h / 20 °C

3: 3.69 percent / sodium pyrosulfite / ethanol; H₂O / 6 h / Heating

4: 84 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 46 h / -40 - 4 °C

5: 768 mg / sodium pyrosulfite / ethanol; H₂O / 20 h / Heating

6: NaOH / 0.5 h / 70 °C

With pyridine; sodium hydroxide; sodium disulfite; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1021/jo051836t

Reference yield:

N-methoxy N-methyl 3,4-dinitrobenzoic acid amide (391903-19-8) → 2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid (874301-24-3)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / Pd/C / ethanol / 4 h / 20 °C

2: 3.69 percent / sodium pyrosulfite / ethanol; H₂O / 6 h / Heating

3: 84 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 46 h / -40 - 4 °C

4: 768 mg / sodium pyrosulfite / ethanol; H₂O / 20 h / Heating

5: NaOH / 0.5 h / 70 °C

With sodium hydroxide; sodium disulfite; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;

DOI:10.1021/jo051836t

upstream raw materials:

2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid methyl ester

3-amino-5-chloro-2-nitrobenzoic acid methyl ester

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde

2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carboxylic acid N-methoxy-N-methylamide