5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Base Information

Chemical Name:5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
CAS No.:1354786-17-6
Molecular Formula:C₂₄H₁₅ClFN₅O₃S₂
Molecular Weight:539.998
Hs Code.:

Synonyms:5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Chemical Property of 5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Technology Process of 5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

There total 3 articles about 5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1354786-72-3
5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

: 1354786-17-6
5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 16h;

Reference yield:

: 71031-48-6
2-iodo-4-phenylphenol

: 1354786-17-6
5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 16 h / 45 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

3: trifluoroacetic acid / 16 h / 20 °C

With copper(l) iodide; potassium carbonate; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; acetonitrile; 1: Stille Coupling;

Reference yield:

: 1354786-56-3
3-Pyridazin-4-ylbiphenyl-4-ol

: 1235406-57-1
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354786-17-6
5-Chloro-2-fluoro-4-[(3-pyridazin-4-ylbiphenyl-4-yl)oxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

2: trifluoroacetic acid / 16 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide;