methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Base Information

• Chemical Name: methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate
• CAS No.: 1179817-49-2
• Molecular Formula: C₁₉H₂₂FNO₂
• Molecular Weight: 315.388

Synonyms:methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Chemical Property of methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Chemical Property:

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Technology Process of methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

There total 1 articles about methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluorobut-2-yne-1-yl chloride (407-80-7) + (-)-Win 35981 (53898-68-3) → methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate (1179817-49-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃; for 12h;

DOI:10.1039/b902863c

Reference yield: 91.0%

methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate (1179817-49-2) → methyl 8-((E)-4-fluorobut-2-en-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/b902863c

Reference yield: 89.0%

methyl 8-(4-fluorobut-2-yn-1-yl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate (1179817-49-2) → methyl 8-(4-fluorobutyl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate (1179817-45-8)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In ethanol;

DOI:10.1039/b902863c

upstream raw materials:

4-fluorobut-2-yne-1-yl chloride

(-)-Win 35981

Downstream raw materials:

methyl 8-(4-fluorobutyl)-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate

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