3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide

Base Information

• Chemical Name: 3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide
• CAS No.: 145486-63-1
• Molecular Formula: C₂₉H₂₈N₆O₂
• Molecular Weight: 492.58
• Mol file: 145486-63-1.mol

Synonyms:3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide

Chemical Property of 3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide

There total 5 articles about 3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<<2'-(N-triphenylmethyl)-tetrazol-5-yl><1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide (168074-29-1) → 3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<2'-(1H-tetrazol-5-yl)<1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide (145486-63-1)

Guidance literature:

With sulfuric acid; In acetonitrile; for 2h;

DOI:10.1080/00397919508015901

Reference yield:

3,3-Dimethylacryloyl chloride (3350-78-5) + 3(R)-amino-1,3,4,5-tetrahydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-2H-1-benzazepin-2-one hydrochloride (145485-04-7) → 3-Methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]but-2-eneamide (145486-63-1)

Guidance literature:

With hydrogenchloride; triethylamine; In methanol; dichloromethane;

Reference yield:

3,3-Dimethylacryloyl chloride (3350-78-5) → 3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<2'-(1H-tetrazol-5-yl)<1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide (145486-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / Et₃N / tetrahydrofuran / 3 h / 22 °C

2: 91 percent / t-BuOK / tetrahydrofuran / 18 h / 22 °C

3: 91 percent / 98percent H₂SO₄ / acetonitrile / 2 h

With sulfuric acid; potassium tert-butylate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1080/00397919508015901

upstream raw materials:

3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<<2'-(N-triphenylmethyl)-tetrazol-5-yl><1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide

3,3-Dimethylacryloyl chloride

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one

3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-(1H)-1-benz-azepin-3-yl>-2-butenamide