2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid

Base Information

• Chemical Name: 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid
• CAS No.: 259738-72-2
• Molecular Formula: C₂₃H₃₉NO₆Si
• Molecular Weight: 453.651
• Mol file: 259738-72-2.mol

Synonyms:2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid

Chemical Property of 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid

There total 8 articles about 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid 2-(tert-butyl-dimethyl-silanyloxy)-ethyl ester → 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid (259738-72-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.5h;

DOI:10.7164/antibiotics.52.1146

Reference yield:

C24H41NO6Si → 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid (259738-72-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

DOI:10.1055/s-0037-1610694

Reference yield:

Boc-Tyr-OH (3978-80-1) → 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid (259738-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 2 h / 70 °C

2: NaH / tetrahydrofuran / 20 h / 0 - 20 °C

3: LiOH / tetrahydrofuran; methanol; H₂O / 0.5 h / 20 °C

With lithium hydroxide; sodium hydride; caesium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1: Alkylation / 2: Methylation / 3: Hydrolysis;

DOI:10.7164/antibiotics.52.1146

upstream raw materials:

Boc-Tyr-OH

2-(tert-butyldimethylsilyloxy)ethyl bromide

2-tert-butoxycarbonylamino-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid 2-(tert-butyl-dimethyl-silanyloxy)-ethyl ester

methyl 3-(4-(2-(benzyloxy)ethoxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate

Downstream raw materials:

(-)-PF₁₁₆₃B

9-(2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionyloxy)-6-methyl-tetradecanoic acid tert-butyl ester

9-(2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionyloxy)-11-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetradecanoic acid tert-butyl ester