2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide

Base Information

• Chemical Name: 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide
• CAS No.: 286959-70-4
• Molecular Formula: C₁₅H₁₀F₃N₃O₃
• Molecular Weight: 337.258
• Mol file: 286959-70-4.mol

Synonyms:2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide

Chemical Property of 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide

There total 2 articles about 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 2-cyano-3-(4-trifluoromethoxyphenyl)-2-butenoate (286959-65-7) + cyanoacetic acid amide (107-91-5) → 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide (286959-70-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 4h;

DOI:10.1021/jm990957g

Reference yield:

1-[4-(trifluoromethoxy)phenyl]ethan-1-one (85013-98-5) → 2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide (286959-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / NH₄OAc; AcOH / toluene / Heating

2: 93 percent / EtONa / ethanol / 4 h / 20 °C

With ammonium acetate; sodium ethanolate; acetic acid; In ethanol; toluene; 1: Knoevenagel condensation / 2: Michael addition;

DOI:10.1021/jm990957g

Reference yield:

2,4-dicyano-3-methyl-3-(4-trifluoromethoxyphenyl)glutarimide (286959-70-4) → 3-(4-trifluoromethoxyphenyl)-3-methylpentanedioic acid (286959-76-0)

Guidance literature:

With sulfuric acid; acetic acid; for 40h; Heating;

DOI:10.1021/jm990957g

upstream raw materials:

ethyl 2-cyano-3-(4-trifluoromethoxyphenyl)-2-butenoate

cyanoacetic acid amide

1-[4-(trifluoromethoxy)phenyl]ethan-1-one

Downstream raw materials:

3-(4-trifluoromethoxyphenyl)-3-methylpentanedioic acid