4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 82493-63-8
• Molecular Formula: C₂₃H₂₈O₆
• Molecular Weight: 400.472
• Mol file: 82493-63-8.mol

Synonyms:4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester

Chemical Property of 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-methoxy-1,3-butadiene (3588-30-5) + (E)-4-(1,4,5-Trimethoxy-naphthalen-2-yl)-but-2-enoic acid ethyl ester (82493-62-7) → 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester (82493-63-8)

Guidance literature:

at 170 ℃; for 48h;

DOI:10.1016/S0040-4039(00)86946-4

Reference yield:

2-allyl-1,4,5-trimethoxynaphthalene (68280-98-8) → 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester (82493-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) osmium tetroxide-potassium chlorate 2.) sodium periodate

2: 70 percent / tetrahydrofuran / Ambient temperature

3: 60 percent / 48 h / 170 °C

With sodium periodate; osmium(VIII) oxide; potassium chlorate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)86946-4

Reference yield:

5-methoxy-2-(2-propenyl)naphthalene-1,4-dione (68280-97-7) → 4-Oxo-2-(1,4,5-trimethoxy-naphthalen-2-ylmethyl)-cyclohexanecarboxylic acid ethyl ester (82493-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) sodium hydrosulphite 2.) K₂CO₃ / 2.) acetone

2: 1.) osmium tetroxide-potassium chlorate 2.) sodium periodate

3: 70 percent / tetrahydrofuran / Ambient temperature

4: 60 percent / 48 h / 170 °C

With sodium periodate; sodium disulfite; osmium(VIII) oxide; potassium chlorate; potassium carbonate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)86946-4

upstream raw materials:

2-methoxy-1,3-butadiene

(E)-4-(1,4,5-Trimethoxy-naphthalen-2-yl)-but-2-enoic acid ethyl ester

2-allyl-1,4,5-trimethoxynaphthalene

1,4,5-trimethoxynaphthalene-2-acetaldehyde

Downstream raw materials:

4-Oxo-2-(1,4,5-trimethoxy-2-naphthylmethyl)cyclohexancarbonsaeure