Technology Process of benzyl 4,5-dimethoxy-6-benzyloxycarbonyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate
There total 13 articles about benzyl 4,5-dimethoxy-6-benzyloxycarbonyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate; thiophenol;
In
acetonitrile;
at 20 ℃;
for 3h;
DOI:10.1021/ja0619455
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrahydrofuran / 1.08 h / 0 - 20 °C
2: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C
3: 425.5 mg / sodium borohydride / methanol / 1 h / 0 - 20 °C
4: copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 80 °C
5: 9.75 g / 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / tetrapropylammonium perruthenate / CH2Cl2 / 1 h / 20 °C
6: 84 percent / 1,1,3,3-tetramethylguanidine / CH2Cl2 / 6 h / 20 °C
7: 77 percent / copper iodide; cesium acetate / dimethylsulfoxide / 12 h / 20 °C
8: 95 percent / cesium carbonate; thiophenol / acetonitrile / 3 h / 20 °C
With
sodium tetrahydroborate; copper(l) iodide; 4 A molecular sieve; cesium acetate; sodium hydrogencarbonate; caesium carbonate; thiophenol; 4-methylmorpholine N-oxide; N,N,N',N'-tetramethylguanidine;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
6: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ja0619455
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 18.16 g / manganese oxide / CH2Cl2 / 18 h / 20 °C
2: tetrahydrofuran / 1.08 h / 0 - 20 °C
3: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C
4: 425.5 mg / sodium borohydride / methanol / 1 h / 0 - 20 °C
5: copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 80 °C
6: 9.75 g / 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / tetrapropylammonium perruthenate / CH2Cl2 / 1 h / 20 °C
7: 84 percent / 1,1,3,3-tetramethylguanidine / CH2Cl2 / 6 h / 20 °C
8: 77 percent / copper iodide; cesium acetate / dimethylsulfoxide / 12 h / 20 °C
9: 95 percent / cesium carbonate; thiophenol / acetonitrile / 3 h / 20 °C
With
manganese oxide; sodium tetrahydroborate; copper(l) iodide; 4 A molecular sieve; cesium acetate; sodium hydrogencarbonate; caesium carbonate; thiophenol; 4-methylmorpholine N-oxide; N,N,N',N'-tetramethylguanidine;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
7: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ja0619455
![benzyl 3-(o-nitrobenzenesulfonyl)-4,5-dimethoxy-6-benzyloxycarbonyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate](/Databaselist/images/loading.webp)
