3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol

Base Information

• Chemical Name: 3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol
• CAS No.: 125874-72-8
• Molecular Formula: C₂₀H₂₄O₆
• Molecular Weight: 360.407
• Mol file: 125874-72-8.mol

Synonyms:3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol

Chemical Property of 3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol

There total 45 articles about 3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

(2S,3R)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-5-[(E)-3-hydroxy-1-propenyl]-3-hydroxymethyl-7-methoxybenzo[b]furan (97465-82-2) → 2α,3β-7-O-methylcedrusin (14049-57-1,79171-87-2,85165-02-2,125874-72-8,126253-41-6,133318-48-6,28199-69-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 1h; Ambient temperature;

DOI:10.1016/0031-9422(95)95268-Y

Reference yield: 77.0%

methyl 3-[2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-2,3-dihydro-1-benzofuran-5-yl]propanoate → 4-[3-Hydroxymethyl-5-(3-hydroxy-propyl)-7-methoxy-2,3-dihydro-benzofuran-2-yl]-2-methoxy-phenol (28199-69-1,85165-02-2,125874-72-8,126253-41-6,133318-48-6,79171-87-2,14049-57-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -15 - 20 ℃;

Reference yield: 74.0%

methyl (E)-3-[2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-2,3-dihydro-1-benzofuran-5-yl]-propanoate → 2α,3β-7-O-methylcedrusin (14049-57-1,79171-87-2,85165-02-2,125874-72-8,126253-41-6,133318-48-6,28199-69-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2019.07.026

upstream raw materials:

3-[(2RS,3SR)-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-7-methoxy-1-benzofuran-5-yl]propyl acetate

2,2-dimethyl-propionic acid 3-{2-[4-(2,2-dimethyl-propionyloxy)-3-methoxy-phenyl]-3-formyl-7-methoxy-2,3-dihydro-benzofuran-5-yl}-propyl ester

4-(3-Hydroxy-propyl)-2-methoxy-6-((E)-propenyl)-phenol

2,2-Dimethyl-propionic acid 3-[4-hydroxy-3-methoxy-5-((E)-propenyl)-phenyl]-propyl ester

Downstream raw materials:

dihydrodehydrodiconiferyl alcohol triacetate

1-Brom-1-(3-methoxy-4-acetoxy-phenyl)-2-<2-acetoxy-3-methoxy-5-(3-acetoxy-propyl)-phenyl>-3-acetoxy-propan

5-(3-hydroxypropyl)-7-methoxy-3-methyl-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran

2α,3β-7-O-methylcedrusin